ROI - ACC

To most of my colleagues, ROI means "region of interest", a connected collection of pixels on a radiological image, and ACC means "anterior cingulate cortex", an interesting and important part of the brain (comprising Brodmann areas 24 & 32). But.

In the world of business, ROI means "return on investment", ACC means "average cost of capital", and their difference, ROI - ACC, means profit. Or loss.